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Colorectal Cancer: Immediate Impact of 2014 ASCO Presentations on Clinical Practice

Colorectal Cancer: Immediate Impact of 2014 ASCO Presentations on Clinical Practice

Introduction

In an effort to provide you with timely market feedback from ASCO 2014, OBR and MDoutlook are pleased to share results from MDoutlook’s OncoPolls™ from the meeting. This first report explored presentations in colorectal cancers (CRC).

OncoPoll™ Methodology

  • Primary research phase involved a global survey to verified and validated medical oncologists and multi-disciplinary physicians with an identified clinical interest in gastrointestinal cancers utilizing targeting parameters within the proprietary MDoutlook® global cancer treater database
  • Timing: June 2014. Launched two days after close of 2014 American Society of Clinical Oncology (ASCO) Annual Meeting, held in Chicago, IL., May 30-June 3, 2014
  • Fielding via <10 minute long interactive internet survey utilizing proven effective methodology via the MDoutlook survey tool
  • Links to discussed abstracts on the ASCO website were provided within the survey
  • Reponses at data collection: 50 on June 24th
  • No financial incentives provided for participation

Geographic Distribution of Respondents

Attendance at 2014 ASCO Annual Meeting

Key Conclusions

  • Nearly three quarters of survey respondents attended this year’s ASCO annual meeting
  • Higher proportion of attendees than in previous years (typically has been a 50/50 split)

Survey Participants’ GI Cancer Patient Flow:  Average Over 13 Cases Each Month

Key Conclusions

  • Survey participants* averaged 35 cases of colorectal cancer last 3 months
    • More than all other gastrointestinal cancers combined
  • Cases of pancreatic cancer were much more common than HCC

* Survey Participants = Medical Oncologists with an identified clinical interest in gastrointestinal cancers

Inclusion of Bevacizumab or Cetuximab with 1st Line Chemotherapy for KRASWT mCRC: Impact of the CALGB/SWOG 80405 Trial

Key Conclusions

  • Results of the CALGB/SWOG 80405 Trial are not going to change treatment usage in the 1st line setting
    • Small increases in cetuximab usage are expected, but not at the expense of bevacizumab
  • Inclusion of biologics with chemotherapy for 1st line setting is going to remain the standard of care
    • FOLFOX is and will remain the standard chemotherapy backbone for mCRC

Adjuvant Chemotherapy for Localized Rectal Cancer: Impact of the ADORE Trial Results

Key Conclusions

  • Oncologists recognize the clinical importance of the ADORE trial
    • Over half rate the presentation as important or higher
  • Due to these results, usage of adjuvant therapy for stage II rectal cancer is expected to increase by over 1/3 from current levels
    • Usage will be nearly 60% of the amount for stage III disease
  • Widespread usage of adjuvant therapy for stage III disease will continue
    • Slight increase to 80% of cases

Conclusions: Impact of ASCO 2014 on Clinical Practices for Colorectal Cancers

  • Colorectal cancer is the main type of gastrointestinal cancers seen in clinical practices
    • Oncologists’ patient flow in colorectal cancer is ~85% of their GI cancer patient flow
  • FOLFOX + bevacizumab is and will remain the most common 1st line treatment approach for KRASWT metastatic colorectal cancer
    • Minor increases in usage of cetuximab are expected, but not at the expense of bevacizumab
    • Chemotherapy with a biologic is the standard of care in the 1st line setting
    • FOLFOX will continue to be preferred over FOLFIRI
  • Adjuvant chemotherapy is seen as an important therapeutic approach for stage II and III rectal cancers
    • A 35% increase in its usage for stage II disease is expected, so that nearly half of patients will receive it
    • Widespread usage for stage III disease will expand even more, to 80% of patients
  • Oncologists use a wide variety of sources to learn about the results presented at ASCO

For a more detailed analysis report, please click here to download the full report.

Submitted by Robert Stephan, Sr. Director Medical Services and Strategy; Jessica Harnisch, Assoc. Global Medical Analyst; Justin Boag, Consultant; and Jan Heybroek, President MDoutlook.

– See more at: http://www.obroncology.com/blog/2014/06/1944/#sthash%2Ew1m9fkiN%2Edpuf

The Giant Colon Celebrates World Cancer Day in Toronto

World Cancer Day is an event designed to reach out to the public on a global scale with the intent to educate and activate conversations about a disease that has effected and continues to affect millions of people around the world.

This year, World Cancer Day 2014 (4 February 2014) focuses on Target 5 of the World Cancer Declaration: Reduce stigma and dispel myths about cancer, under the tagline “Debunk the myths”.

According to organizers, World Cancer Day is a chance to raise our collective voices in the name of improving general knowledge around cancer and dismissing misconceptions about the disease. From a global level, we are focusing our messaging on the four myths above. In addition to being in-line with our global advocacy goals, these overarching myths leave a lot of flexibility for members, partners and supporters to adapt and expand on for their own needs.

Visit the website for more details on World Cancer Day and the 658 events organized and on-going around the world today. One of which is the presence of The Giant Colon Tour in the Mars Building in Toronto.

The 40-foot long, eight-foot high inflatable exhibit, which features many unappealing pre-cancerous and cancerous sites throughout, is an attention-grabbing prop used as part of the Colorectal Cancer Awareness Association’s awareness raising campaign on the second leading cause of cancer deaths in Canada.

Visitors are guided through the colon by a puppet mascot, Dr. Preventino, who appears on a series of screens to show them giant hemorrhoids, rectal cancer, mushroom-like polyps and other not-so-pleasant things one might see during a colonoscopy. The tour aims to inform visitors in a fun, graphic and memorable way, that colorectal cancer is both preventable and treatable.

The tour aims to inform visitors in a fun, graphic and memorable way, that colorectal cancer is both preventable and treatable.

If you haven’t had the chance to take a tour yet, it will be set-up in the Mars building today Feb 4th until 8:30PM.

Get in there while you can!

Sanofi Canada Donates $65,000 to the CCAC’s Giant Colon Tour Initiatives

The Colorectal Cancer Association of Canada was pleased to accept a generous donation of $65,000 from Sanofi Canada and it’s employees to fund its vital awareness, support and advocacy activities.

Sanofi Canada employees were encouraged to take an educational tour of the CCAC’s 40’ long, walk through, multi- media, supersized representation of the human Colon that was installed at their annual National Meeting, on January 21 and 22. For each employee who took the tour, Sanofi Canada pledged to donate $5 to the association.
“With over 400 employees having taken The Giant Colon tour, many more than once, employees raised almost $6,500 for the Colorectal Cancer Association of Canada. As a result of their overwhelming support of the fundraising effort, Sanofi Canada decided to add a zero to the amount and raise the donation to $65,000,” claims Jon Fairest, President and CEO, Sanofi Canada. “Our goal is to be a true partner in health to Canadians and this is one way we achieve this. We are proud to partner with and contribute to the association and the important work it does.”

“We greatly appreciate our long-standing relationship with Sanofi Canada and ongoing support they provide the Colorectal Cancer Association of Canada in our efforts to increase awareness and education of the disease. With Sanofi’s help The Giant Colon became a reality in Canada, the result of which has been that millions of Canadians have learned about colorectal cancer and how it can be prevented,” said Barry D. Stein, President, Colorectal Cancer Association of Canada.

In 2013, 1 in 13 men and 1 in 15 women were diagnosed with colorectal cancer in Canada. Colorectal cancer is linked to several modifiable risk factors, emphasizing the importance of primary prevention and timely screening.

Stay tuned to our Facebook Page in order to know when The Giant Colon will be making a stop in a city near you!

The Giant Colon visits Sherbrooke

The Giant Colon Tour made a 3 day stop from August 9th to 10th at The Carrefour de L’Estrie in the beautiful city of Sherbrooke, Quebec. The people from the Sherbrooke region were extremely gracious hosts and close to 7,000 of them passed through our fabulous 40 foot long interactive awareness exhibit. Since the Canada Games were also taking place during our stay, there were numerous out of town and out of province visitors.

Special thanks to Francine Chenard and Sophie Breault from the Carrefour de l’Estrie, Nathalie Guay and Pierre-Étienne Fillion from the CHUS laboratory and Gordon Lambie from The Record.

Our fabulous volunteers Hugo Douville and Jeannette Pane joined CCAC staffers David Black and Frank Pitman to make the Sherbrooke stop one of the most successful this year.

In the Name of the Father – Chris McGrath to Run the Toronto Waterfront Marathon This Fall

This year, close to 24-thousand Canadians will be diagnosed with colorectal cancer. George McGrath, 56, is among them. Diagnosed in June, he just started chemotherapy and radiation treatment. In the meantime, his 25-year-old son Chris, is using social media combined with his networking skills to lift his father’s spirits, all the while training to run in the Scotiabank Toronto Waterfront Marathon this fall in his father’s honour.

“I was able to wrangle up four friends who would like to do (the run) with me as well and they’re all really close with my dad too so it’s kind of taken off from there,” Mr. McGrath says.
The group — including Mr. McGrath, Dana Liddell, David Rostek, Matthew Rostek and Kevin Huinink — has already raised more than $3,000 within a few days and is aiming for a total of $10,000.

Help support Chris McGrath for the CCAC.

http://my.e2rm.com/personalPage.aspxregistrationID=1989138&langPref=en-CA

University of Ottawa Imagination Session

A team of volunteer student consultants from the Telfer School of Management’s MBA program is currently working with the CCAC to develop new event ideas and provide the framework in which the event will be successful and sustainable. To that end, an Imagination Session was held on July 24th at the Telfer School of Management on the University of Ottawa’s main campus. A total of 16 students participated in the event. Seven different faculties were represented at the event; Arts, Common Law, Civil Law, Engineering, Management, Medicine, and Science. 61 original ideas were generated at this morning-long session.

The structure of the Imagination Session was developed based on the study of research carried out by academics and practitioners. A number of subtle nuances were critical for the event’s success. While the group should not be too large or too small, there should also be an open flow of ideas. However, too open of a setting can prove intimidating for some participants, so there should be clear guidelines but they should not be restrictively specific. In this context, the structure of the event was developed.

The event started with an introductory presentation, necessary for providing the background and context in which the session fits. The background information included a presentation of CCAC as well as an overview of colorectal cancer. Idea information was then provided, including other events currently run by CCAC as well as the full range of creative to traditional events currently held in Canada. Finally, the session agenda was presented, with a strict timeline and objectives, and session rules were provided.

Small groups of four participants developed original ideas, while a designated scribe recorded the ideas on poster board. After 15 minutes of brainstorming, the scribes switched groups and presented the ideas generated by the previous group. These existing ideas were then built on by the new group and used as inspiration for new ideas. This process continued until the scribes had rotated amongst all groups. This structure allowed ideas to flow freely through the use of smaller groups, but also allowed all participants’ ideas to influence and inspire other ideas by having scribes that switched groups.

The ideas, frameworks for success, performance management techniques, as well as high-level implementation plans will be presented to the CCAC in the consultants’ final report, to be delivered and presented by mid-August.

Written by Guest Blogger:
Vincenzo Sposato
JD/MBA Candidate 2014 (uOttawa)

2nd Annual Rollin’ for Colon A Huge Success

The 2nd Annual Rollin’ for Colon event took place July 19, 20, 21, 2013. Eighty-eight people attended and a great time was had by all. Our event was the first of its kind in Canada because it is a motorcycle & motor coach tour bus event. Everyone and anyone can participate, not only motorcyclists.

On Friday evening, the 19th, registrants were treated to a free seafood before preparing for the following day’s all day tour and poker run. The fog was thick and extremely wet when the participants left Yarmouth by way of the South Shore and also the Annapolis Valley on Saturday morning at 9:00 am. It was more than an hour into their trip before the fog lifted and the sun broke through the clouds. Returning home to Yarmouth that evening, participants were treated to a quarter chicken dinner with all the fixings plus a cake for dessert which was donated by Atlantic Super Store (Loblaws).

This year we sold raffle tickets on a motorcycle training course as well as having an auction of donated items. Proceeds from the auction and raffle were donated to two local cancer support groups – The Gilles Boudreau Cancer Care Fund and the Yarmouth Prostate Cancer Support group. Both groups assist cancer patients with travel costs to and from other hospitals for treatments and/or doctors’ appointments, if treatments and /or specialists are not available at the South West Health Cancer Centre in Yarmouth. This year we are fortunate to be able to donate $500 each to the above mentioned groups. We were pleased to be able to donate locally as well as raise money for CCAC.

The best part of this event – we raised $1800.00 for the Colorectal Cancer Association of Canada. This was down slightly from last year as our event this year was during a time that most people chose to take their vacations.

Jen’s Booty Banter: Spice up your Summer

Booty Banter has been on a hiatus. I should be spanked, but alas the pooping princess is back and I look forward to regaling with ways to stay regular, because I am obsessed as ever to get you tips you can actually use to keep things moving along.

Before I give you a hot idea though, a couple of months ago, I read some statistics that were both encouraging and alarming. Here’s the good news. Colorectal cancer rates overall seem to be going down. This is fantastic. But the downside is that the number of younger people (25 -49) developing bum cancer is slowly increasing. Why? It’s hard to say but speaking as someone who has sometimes lived it hard, lifestyle choices might have something to do with it. That and all the other stuff you can’t control, like family history and environmental factors (which I am convinced have health impacts). All I can say about this one, is if you are young(ish) like me and in your forties and think you’re too young to get cancer in the pooper, you’re wrong. At ANY sign of trouble, if something just doesn’t feel right, or you have blood, cramps or general malaise down there insist on a colonoscopy. Don’t let your doctor tell you that you are too young to get it. You aren’t. Ok enough of the serious stuff. And as I have said in the past, the colonoscopy just isn’t that bad and the drugs they give you to get you through the procedure are the best.

I could also go on about the importance of exercising and eating veggies (which of course it all is) but you hear that all the time from just about everywhere you look. Enough said, for now anyway.

But here’s the bottom line. In a way, your bum health is about revving up the metabolism, keeping it going fast enough for all your parts to do their job more efficiently and to get the toxins moving out of your body as fast as possible.
On that note, have you ever noticed how, after a particularly spicy meal, it’s not just your mouth that is on fire? For starters, if you are looking at keeping your trim figure, spices help crank up your metabolism so you are burning more calories, especially hot peppers. That in turn helps out in the poop-producing department. Adding garlic, turmeric, cinnamon and curry not only make your food taste better, they too help your digestive system keep ticking along too. So don’t be afraid to spice up your life up a bit with some easy butt-moving additions to your diet. Next month, I will share a list of spices and other taste-enhancing butt-friendly elements that you can add to your food.

In the meantime, make sure you also drink lots of water.

Jennifer Hartley is a features writer and copy editor for Ottawa Life Magazine and writer for Ottawa Outdoors Magazine. Previously she was theatre editor for Ottawa Xpress and now defunct Metro newspaper and has written articles for a variety of magazines across the country and abroad in the United Kingdom.

Survivor Series – Margaret Podgorski

My name is Margaret Podgorski.

I was diagnosed with stage IV colorectal cancer in January of 2009. Since then I have been thinking of myself as Stage Four Colorectal Cancer. This may still change, but I understand better every day, that it most likely will not and hopefully would last a long time. In other words, I am learning to live with my cancer. I respect it. It is mine and I intend to heal it.
Like so many cancer patients I decided, that this is an opportunity to make all the positive changes in my life, changes I was planning to make for so long. And I did, almost overnight, and it worked. It did not take long before I started feeling better than ever. I changed my diet, started taking all sorts of supplements, started to exercise more and tried every complementary treatment that managed to convince me of its merits. And I still do, and I still feel great.

A month after the diagnosis I had my primary tumour removed. Pathology report confirmed initial diagnosis and a couple of weeks later doctors started planning my future treatment. I remember the feeling of helplessness, the need to know and understand what is being done to me. Asking relevant questions requires knowledge. I had to learn as much as possible. From day one I wanted to know everything about MY cancer. I wanted to understand it. I had to in order to fight it. I turned to internet. The amount of information overwhelmed me. The dread of chemo was approaching and I was working so hard to get rid of my cancer before it started, before it would have a chance to poison my newly cleansed body… fat chance. The CT scan prior to my first chemo showed significant progression in both my lungs and my liver. The oncologist was talking about palliative treatment and I was feeling healthier than I have ever felt before… Dying…? When…? 6 months… Who knows…? Confusion. This was my lowest point. It lasted just a moment but I know it had the potential of breaking me. Fortunately I quickly remembered that I was feeling great and I could take the chemo no problem. Bring it on… I started in April of 2009 and I tolerated it quite well.

At the same time I was exploring the world of support groups. Every one of them had so much to offer, yet I kept on looking for a group focused on understanding MY disease and treatments. My husband stumbled upon Barry Stein’s story and found out about the Colorectal Cancer Association of Canada Cancer Coach Conference that was taking place in Toronto in May of 2009. We met this group of wonderful people, all touched by MY cancer and all bend on educating colorectal cancer patients about the disease and treatment options.
My wish has been granted?

This experience and continuous CCAC group support gave me new confidence. I realized, I would never know all about my cancer but there will always be something new to learn. Now I have back-up, advice, people who know and who can help. It helped me relax. It helped me accept the treatments.

In February of 2010 I had liver resection followed by more chemo and in early 2011 I had my left and then my right lung resected. More chemo followed and in January 2012 my second liver resection was done. Another set of lung resections was scheduled in 2012 but it fell through because of recurrence in my liver. In July 2012 I started chemo yet again. I was told that surgery is not an option for my liver or my lungs anymore, so with the CCAC’s help we looked for other options. She found one and I started radiation treatment for my lungs in January 2013. This took 2 months and on April 15/13 I had full body PET/CT done at the clinic where I received radiation treatment. Suddenly the focus changed. The scan revealed several tumors in my brain. Fortunately they were discovered early. I completed full brain radiation and now at the end of May 2013 I am back on chemo – my favourite FOLFIRI & AVASTIN. Awaiting good news

I am here. I feel great. Yes, I know, I most likely will die of MY cancer.

When? Who knows….?

Margaret Podgorski

The Giant Colon makes a stop in Quebec City

The Giant Colon Tour stopped in Quebec City for three days from May 9 -11 as part of the Salon Vancances Évasion in Les Galeries de la Capitale. Over 6,500 people passed through our fabulous interactive 40 ft. long colon.

Many thanks to our great volunteers Jeannette Pane and Jacynthe Boudreault who joined staffers Dave Black and Frank Pitman to help spread colorectal cancer awareness.