Colorectal Cancer Association of Canada - CCAC

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Researchers Identify Toxic Mushroom-Based Drug To Fight Colorectal Cancer

A toxin called alpha-amanatin, derived from “death cap” mushrooms was considered for some time as a potential treatment for colorectal cancer. But since the toxin is known to cause liver toxicity, there have been limitations to enable its use as a potential effective therapy.

In a recent study published in Nature, a team of researchers at The University of Texas MD Anderson Cancer Center led by Xiongbin Lu, Ph.D., associate professor of Cancer Biology investigated the alpha-amanatin derived antibody drug conjugates (ADCs) as one potential solution.

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